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Annual Meeting of the GTA

May 3-4, 2018
John M. Clayton Hall Conference Center
University of Delaware
Newark, DE

Speakers Bios, Abstracts & Presentations

Keynote Speaker:

Yan Zhang
University of Michigan

CRISPR Overview and Practical Applications

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Symposium I: CRISPR, a powerful new technology: Applications and regulatory issues

Eric Kmiec
Helen F. Graham Cancer Center

CRISPR-Directed Gene Editing in vitro; a Novel System for the Identification of Regulatory and Genotoxic Factors in a Cell-Free Environment

Marco Jost
UCSF

Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that
Rigosertib is a Microtubule-Destabilizing Agent

Sandhya Sanduja
US FDA

Regulatory Considerations for CRISPR/Cas-based Gene Edited Products: An FDA Perspective

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Symposium II: Case Studies/Key Problems in Genetic Toxicology

John Nicolette
Abbvie

Case Study: I Can See Clearly Now (Genetox is Done!)

Zhanna Sobol
Pfizer Worldwide Research and Development

Sex, Drugs and GeneTox

Krista Dobo
Pfizer Worldwide Research and Development

Risk Assessment of Two Mutagenic Diboron Reagents

Richard Williams
Lhasa

Are All Ames Strains in the OECD Mutagenicity Test Guideline 471 Useful and Necessary? An Analysis of Large Mutagenicity Data Sets for the IWGT

Abstract coming soon.

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Symposium III: Case Studies Focus Topic: Aryl Boronic Acids in Pharmaceutical Development

Joel Bercu
Gilead

Introduction and Review of Bacterial Mutagenicity of Aryl Boronic Acids

Michelle Kenyon / Vijay Reddy
Pfizer Worldwide Research and Development / Merck

Genotixicity of Aryl Boronic Acids In Vitro in Mammalian Cells

Melisa Masuda-Herrera
Gilead

In Vivo Genotoxicity of Aryl Boronic Acids

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Symposium IV: IWGT 2017 Update

Rodger Curren

Errol Zeiger

Maik Schuler

Bhaskar Gollapudi

Dan Levy

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Symposium V: Tools and Approaches for Clinical Biomonitoring of Genomic Damage

Zach Nagel
Harvard University

Comprehensive Analysis of DNA Repair Capacity in Human Leukocyte Subtypes

Qingyi Wei
Duke University

Genetic Variant in DNA Repair Gene GTF2H4 is Associated with Lung Cancer Risk

Robert Sobol
University of South Alabama Mitchell Cancer Institute

Advanced Tools for DNA Repair and DNA Damage Analysis

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Symposium VI: Mechanisms of Actions

Chris Corton
US EPA

New Application of Predictive Toxicogenomic Signatures to Identify
Genotoxic Agents

Liz Rubitski
Pfizer Worldwide Research and Development

The Role of Cellular Imaging in the Mode of Action Assessment of
Clastogens and Aneugens

Nikolai Chepelev
Health Canada

Genotoxic Mode of Action of Acrylamide

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